In vitro antimicrobial efficacy of root extracts of Murraya koenigii (Linn.) antimicrobial properties and hence can be exploited for future natural plant based. ANTIBACTERIAL ACTIVITY OF Murraya koenigii AGAINST FEW Staphylococcus spp. AND DEVELOPMENT OF A TOPICAL CREAM. Antibacterial, antifungal and anthelmintic activity of curry leaves Murraya koenigii (L.) spreng. Afzal, F. (Karachi Univ. (Pakistan). Inst. of Environmental Studies).

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Murraya koenigiifamily Rutaceae, commonly known as Murrayaa leaf plant is a highly valued plant for its medicinal value and characteristic aroma. The plant is a rich source of carbazole alkaloids.

The petroleum ether, chloroform, ethyl acetate and ethanol extracts of koenigii of the plant were screened for phytochemical properties and antimicrobial activity for Staphylococcus aureus, Micrococcus luteus, Bacillus antibacteral, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger.

Phytochemical screening showed the presence of carbohydrates, alkaloids, steroids and flavonoids in the root extracts of the plant. The study shows that all the extracts possess remarkable antibacterial activity. Additionally, petroleum ether and chloroform extracts also had antifungal activity. Murraya koenigii Linn, Spreng. Family-Rutaceae commonly called Curry leaves in trade, occurs throughout India up to an altitude of metres 1.

The leaves of the plant are used as a flavoring agent.

Antibacterial, antifungal and anthelmintic activity of curry leaves Murraya koenigii (L.) spreng

Medicinally, these leaves found use in diarrhea, dysentery and to prevent vomiting. The Leaves and fruits are also a source of an essential oil which finds use as a fixative for heavy type of soap perfume.

Leaves, root and bark are tonic, stomachic and carminative. Juice of roots provides relief from renal pain 8. Previous phytochemical investigations on this plant revealed the presence of carbazole alkaloids 36101213141516 and coumarins 2.

The present study is aimed at preliminary phytochemical screening of the root antiabcterial of Murraya koenigii and evaluation of the same for potential antimicrobial activity. Nutrient agar and Sabouraud dextrose agar media were obtained from Himedia, India. Ciprofloxacin and Fluconazole were a okenigii gift from Ranbaxy Laboratories Ltd.


The roots of Murraya koenigii were collected in Octoberfrom healthy plants in Ambala, India and shade dried. The identity of each test organism was confirmed using standard cultural, morphological and koneigii techniques 4.

All the experimentation was done in aseptic area under laminar air-flow cabinet. Modified agar diffusion method 7 was adopted for this study. Molten agar medium 25 ml was taken in a sterile petridish and broth cultures of the test isolate 0. The contents were thoroughly antibacterizl and allowed to solidify.

At the end of incubation, zone of inhibition was measured in all the plates. The extractive values for petroleum ether, chloroform, ethyl acetate and ethanol extracts was found to be 4. The results of the phytochemical screening Table 1 showed the presence of carbohydrates in all the extracts except chloroform extract and chloroform extract showed the presence of alkaloids.

The flavonoids and sterols were found to present in ethyl acetate and ethanol extracts. Petroleum ether and chloroform extracts exhibited prominent antibacterial and antifungal activity Table 3.

The chloroform extract is showing good inhibitory properties for A. The MIC values of the extract against tested microorganisms are shown in Table 2.

The results of the tests for MIC study revealed that the MIC for Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli were found to be activitu than that Staphylococcus aureus and Micrococcus luteus. Comparision of antimicrobial activity of various extracts of root of Murraya koenigii.

All the extracts of Murraya koenigii roots have antimicrobial property. As expected, the zone of inhibition antimicrobial activity is directly proportional to the extract concentration koenigij.

The Petroleum ether is inhibitory against A. The data shows E. Also, ethyl acetate and ethanolic extracts showed antibacterial activity but lacks any antifungal activity. These results shows that the root extract chloroform, Petroleum ether can be used to formulate antimicrobial compositions.


However, further investigation activiry purified fractions is required to predict the exact mechanism of action. National Center for Biotechnology InformationU. Journal List Braz J Microbiol v. Published online Dec 1.

actiivity Author information Article notes Copyright and License information Disclaimer. Received Jul 22; Accepted May All the content of the journal, except where otherwise noted, is licensed under koeniigii Creative Commons License.

This article has been cited by other articles in PMC. Abstract Murraya koenigiifamily Rutaceae, commonly known as Curry leaf plant is a highly valued plant for its medicinal value and characteristic aroma. Murraya koenigiiRutaceae, phytochemical screening, antimicrobial activity.

Evaluation of antimicrobial activity All the experimentation was done in aseptic area under laminar air-flow cabinet. Table 1 Phytochemical screening of extracts of root of Murraya koenigii. Open in a separate window. Table 3 Antimicrobial murarya zone of inhibition of extracts of root of Murraya koenigii. Cipro-ciprofloxacin, Fluco-fluconazole, NA-not applicable.

Minor furocoumarins of Murraya koenigii. Structures of the carbazole alkaloid isomurrayazoline from Murraya koenigii. Preparation of the test organisms.

Antibacterial, antifungal and anthelmintic activity of curry leaves Murraya koenigii (L.) spreng

Chapman and Hall Limited; Alkaloidal constituents of Murraya koenigii —isolation and structural elucidation of novel binary carbazolequinones and carbazole alkaloids. Antimicrobial activity of Polygonum tinctorium Lour. Lalit Mohan Basu Publishing; Antibacterial, antifungal and cytotoxic activities of tuberous roots of Amorphophallus campanulatus.

A comparative murrays of the phytochemical and antimicrobial properties of the Eastern Nigerian species of African Mistle foe Loranthus nucranthus sourced from different host trees.

Biologically active carbazole alkaloids from Murraya koenigii. Mahanimbinol from Murraya koenigii. Two carbazole alkaloids from Murraya koenigii.

Carbazoquinones from Murraya koenigii. Antioxidative activity of carbazoles from Murraya koenigii. English Language Book Society; Articles from Brazilian Journal of Microbiology are provided here courtesy of Elsevier.

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