APIXABAN NEJM PDF

Original Article from The New England Journal of Medicine — Oral Apixaban for the Treatment of Acute Venous Thromboembolism. Apixaban, an oral, direct factor Xa inhibitor, may reduce the risk of recurrent ischemic events when added to antiplatelet therapy after an acute coronary. Original Article from The New England Journal of Medicine — Apixaban in Patients with Atrial Fibrillation.

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Whether direct oral anticoagulants DOACs would be safe and effective for this indication is unclear.

To address this issue, investigators conducted an industry-funded, randomized, placebo-controlled, double-blind trial of the direct factor Xa inhibitor apixaban 2. Apixaban or placebo was given within 24 hours of starting chemotherapy and continued for 6 months. VTE was less frequent in patients assigned to apixaban versus placebo 4.

FDA approves antidote for factor Xa inhibitors

Major bleeding occurred more often with apixaban 3. No between-group differences were seen in the rates of adverse events and deaths. Patients with active malignancies are at risk for VTE but do not always receive prophylactic anticoagulants because of concerns about bleeding, need for injections, and cost.

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DOACs appear to be as effective as LMWH and are more acceptable to patients, but they pose similar risks for bleeding and should be used cautiously in those with gastrointestinal malignancies, apixabn impairment, or thrombocytopenia.

Carrier M et al. Apixaban to prevent venous thromboembolism in patients with cancer.

FDA approves antidote for factor Xa inhibitors |

N Engl J Med Dec 4; [e-pub]. J Clin Oncol Dec 7. National Comprehensive Cancer Network guidelines for multigene panel testing miss nearly half of patients with actionable variants. Lancet Oncol Nov 1. N Engl J Med Dec 1.

Universimed Portal – View Nejm

Older patients with previously untreated disease had better outcomes with ibrutinib than with chemo-immunotherapy. Blood Dec 3, Kulasekararaj AG et al. Blood Dec 3. Ravulizumab was noninferior to eculizumab in both previously treated and treatment-naive patients.

Forty percent of apjxaban with relapsed or refractory disease achieved complete remission. N Engl J Med Dec At 23 years of follow-up, life expectancy was nearly 3 years longer with prostatectomy than with watchful waiting.

N Engl J Med Dec 4.

Venous thromboembolism occurred less frequently with the direct oral anticoagulant apixaban than with placebo. Comment Patients with active malignancies are at risk for VTE but do not always receive prophylactic anticoagulants because of concerns about bleeding, need for injections, and cost. Gradishar, MD Highlights of the latest research.

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Genetic Testing for Breast Cancer: How Effective Are Guidelines? J Clin Oncol Dec 7 National Comprehensive Cancer Network guidelines for multigene panel testing miss nearly half of patients with actionable variants. Gradishar, MD A perspective on the most important research in the field from the past year. N Engl J Med Dec 1 Older patients with previously untreated disease had better apixabab with ibrutinib than with chemo-immunotherapy.

Blood Dec 3 Ravulizumab was noninferior to eculizumab in both previously treated and treatment-naive patients. N Engl J Med Dec 1 Forty percent of patients with relapsed or refractory disease achieved complete remission.

N Engl J Med Dec 13 At 23 years of follow-up, life expectancy was nearly 3 years longer with prostatectomy than with watchful waiting.

N Engl J Med Dec 4 Venous thromboembolism occurred less frequently with the direct oral anticoagulant apixaban than with placebo. Wenn Sie fortfahren, nehmen wir an, dass Sie mit der Verwendung von Cookies auf dieser Webseite einverstanden sind.