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Cau, Pierre Overview. Most widely held works by Pierre Cau.
Cau, Pierre 1947-
Cours de biologie cellulaire by Pierre Cau Book 9 editions published between and in French and held by WorldCat member libraries worldwide. Morphogenesis of thyroid follicles in vitro by Pierre Cau Book 8 editions published in ccellulaire English and held by WorldCat member libraries worldwide The thyroid gland first appears in the phylogenic scale cellulairs the Lamprey larva, Ammocoetes, at the time of metamorphosis see review by Constantinescu, In higher Vertebrates the adult thyroid gland consists of vesicles i.
Since the end of the 19th century, many authors have studied the morphoge nesis of the follicles during the embryonic and fetal development of the gland in Man and other species, principally Chick, Rat and Rabbit. The development of techniques for culturing organs of higher animals, in particular the thyroid by Carrel and Burrows and Champy, allowed the study of the survival in vivo or in vitro of grafts or explants of thyroid gland obtained from adult or fetal animals.
In addition cellulairs organotypic cultures, techniques for culturing cell suspensions obtained by enzymatic dissociation have recently been refined.
Moreover, histological examination of pathological human glands and adult thyroids experimentally stimulated by thyrotropin hormone TSH has provided additional data for the understanding celluoaire thyroid follicle morphogenesis.
An abnormal protein, progerin, synthesized in a rare genetic disease called Progeria resulting in child accelerated aging, cellulairf accumulates during physiological aging, pierrr the absence of mutation, in nucleus of cells, particularly keratinocytes and dermal fibroblasts. The toxicity of pierrre is related to bilogie persistence of an isoprenoid group, which anchors the progerin to the nucleoplasmic face of the nuclear envelope, and causes abnormalities in the nuclear matrix composition and functions.
It has been demonstrated that a combination of a statin and an aminobisphosphonate reduces the synthesis of isoprenoid group and reduces as well the cellular toxicity of progerin. The first part of this work is to study in vivo, on mouse ear, the effect of a topical administration of a statin-aminobisphosphonate combination. An oil-in-water emulsion containing two molecules has been developed and applied on the right mouse ear during 28 days; a placebo formula was applied on the left ear.
A histological study and a quantitative microscopy analysis show that the topical application of the statin-aminobisphosphonate combination statistically increases ermal thickness, the increase in both epidermis and cartilage thickness being at the limit of statistical significance.
We can conclude that both topically administered molecules penetrate the different skin layers. In a second time, in order to quantify the rate of percutaneous absorption of active ingredients, a diffusion study was performed in vitro on pig ear skin via static Franz diffusion cells. The results confirmed the cutaneous passage of the two active ingredients and helped to determine their topical bioavailability.
Cau, Pierre [WorldCat Identities]
For cosmetic applications, the systemic exposure dose SED was used to calculate the margin of safety MS required by cosmetic regulatory rules. In order to verify the activity of the statin-aminobiphosphonates association on skin aging, a comparative, double-blind, randomized clinical study was then conducted in humans during three months. Objective physical measurements of skin micro-relief on crows’ feet and of the hollow cheek were performed at time 0 and after 28, 56 and 84 days of cosmetic treatment.
By comparison with a placebo and with a commercially available cosmetic, the cosmetic preparation containing the statin4 aminobisphosphonate combination leads to a statistically significant reduction of fine lines and wrinkles and a decrease in volume of the bioolgie of the cheek. Thus, the statin-aminobisphosphonate combination exhibits skin anti-aging properties.
De plus, l’expression placentaire de CD et fau concentrations de CDs varient au cours de grossesses pathologiques. The “iterative deconvolution” procedure used in the analysis by the “cross-fire method” of electron microscope autoradiograms ; application to the detection membrane sources by Pierre Cau 1 edition published in in English and held by 1 WorldCat member library worldwide.
They arise from a multipotent embryonic cell population called the neural crest, which also gives rise to the peripheral nervous system of the body and many other cell types. Abnormal proliferation of melanocyte precursors before birth can lead to human congenital melanocytic nevus CMN. The largest CMN, covering entire segments of the body or head, are syndromic.
BrafVE mutant embryos are embryonic lethal at mid-gestation, probably due to coinciding vascular and brain defects. In contrast, NrasG12D mice are viable, present extracutaneous melanocytosis in various sites as well as postnatal hyperpigmentation of the skin.
This is associated with increased hair follicle density, and a deregulated hair cycle. Cell culture cxu mutant or wildtype mouse neural crest cells of both genotypes has permitted the comparison and discovery of molecular differences introduced by these mutations. Cytology Medicine Morphogenesis Organ culture Thyroid gland.
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